To ensure no blanks are allowed in a drop-down list from a named range, what action should be taken during validation?

To ensure no blanks are allowed in a drop-down list created from a named range, it is essential to uncheck the Ignore blank box during the data validation setup.

When the Ignore blank box is checked, the data validation will permit blank entries in the drop-down list, allowing users to leave the cell empty without triggering a validation error. By unchecking this option, the validation rule enforces that every selection must come from the available entries in the named range, effectively preventing any blank submissions.

This action directly impacts how the validation operates, ensuring that users are required to make a selection from the provided list, thus maintaining data integrity and preventing incomplete entries in your dataset.